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PhD in Pharmaceutical Sciences

General informations

Duration: 3 years
Program coordinator: Prof. Giancarlo Aldini

dottorato.scifarm@unimi.it


Outline and objectives

The PhD course in Pharmaceutical Sciences, by offering interdisciplinary training, prepares students for careers in academia and advanced scientific research at a variety of institutions/companies active in the field of drug and health products. The program, which consists of both lectures and intensive experimental research, emphasizes basic as well as applied research in drug discovery and development, drug delivery and targeting, exploiting medicinal chemistry, computational chemistry, pharmaceutics, pharmacokinetics, phytochemistry, and analytical chemistry approaches. Students enjoy the opportunity to enroll in a variety of didactic courses and engage in multidisciplinary research activities. They will gain the knowledge and skills required not only for the rational approach to new biologically active compounds, for the discovery of novel biological pathways in human health and disease, and for the development and delivery of new medications for safe and effective therapy, but also for developing biocides, medical devices, functional foods, food supplements, cosmetic products.


Main scientific research fields

• Design and synthesis of biologically active compounds
• Pharmaceutical, biopharmaceutical and toxicological analysis
• Drug metabolism and pharmacokinetics
• Pharmaceutical technology and legislation
• Food chemistry and food supplements
• Fermentation chemistry and biotechnology
• Advanced synthetic methodologies
• Physico-chemical characterization of biologically active compounds
• Herbal drugs, botanicals and active ingredients of plant origin
• Statistical methods for experimental data processing.


Detailed informations can be found at the following links:

Dipartimento di Scienze Farmaceutiche: http://www.disfarm.unimi.it/ecm/home/ricerca
CNR, Istituto di Chimica per il Riconoscimento Molecolare: http://www.icrm.cnr.it/

Contacts

Director - Secretary - Webmaster Ariel

Director
Prof. Giancarlo Aldini
Dipartimento di Scienze Farmaceutiche, Via Mangiagalli 25, 20133 Milano
e-mail: giancarlo.aldini@unimi.it; Telefono: 02-50319296

Secretary
Sig.ra Iolanda Gentile
Dipartimento di Scienze Farmaceutiche, Via Mangiagalli 25, 20133 Milano
e-mail: iolanda.gentile@unimi.it; Telefono: 02-50319338

Webmaster Ariel
Prof.ssa Elisabetta Rossi
Dipartimento di Scienze Farmaceutiche, Via Venezian, 21, 20133 Milano
e-mail: elisabetta.rossi@unimi.it; Telefono: 02-50314474

Academic board

Academic board


ABBIATI Giorgio, UNIMI, Dipartimento di Scienze farmaceutiche, Professore Associato, Chimica Organica

ALDINI Giancarlo, UNIMI, Dipartimento di Scienze farmaceutiche, Professore Ordinario, Chimica Farmaceutica

ARNOLDI Anna, UNIMI, Dipartimento di Scienze farmaceutiche, Professore Ordinario, Chimica degli Alimenti

BECCALLI Egle Maria, UNIMI, Dipartimento di Scienze farmaceutiche, Professore Ordinario, Chimica Organica

BERETTA Giangiacomo, UNIMI, Dipartimento di Scienze farmaceutiche, Ricercatore, Chimica Farmaceutica

BOLCHI Cristiano, UNIMI, Dipartimento di Scienze farmaceutiche, Ricercatore, Chimica Farmaceutica

CARINI Marina, UNIMI, Dipartimento di Scienze farmaceutiche, Professore Ordinario, Chimica Farmaceutica

CEREA Matteo, UNIMI, Dipartimento di Scienze farmaceutiche, Ricercatore, Farmaceutico Tecnologico Applicativo

CHIARI Marcella, CNR, Istituto di Chimica del riconoscimento molecolare, Primo Ricercatore

CILURZO Francesco, UNIMI, Dipartimento di Scienze farmaceutiche, Professore Associato, Farmaceutico Tecnologico Applicativo

CLERICI Francesca, UNIMI, Dipartimento di Scienze farmaceutiche, Professore Associato, Chimica Organica

COLOMBO Giorgio, CNR, Istituto di Chimica del riconoscimento molecolare, Primo Ricercatore, Chimica Farmaceutica

CONTINI Alessandro, UNIMI, Dipartimento di Scienze farmaceutiche, Professore Associato, Chimica Organica

DALLANOCE Clelia, UNIMI, Dipartimento di Scienze farmaceutiche, Professore Associato, Chimica Farmaceutica

DE AMICI Marco, UNIMI, Dipartimento di Scienze farmaceutiche, Professore Ordinario, Chimica Farmaceutica

FICO Gelsomina, UNIMI, Dipartimento di Scienze farmaceutiche, Professore Associato, Biologia Farmaceutica

FOPPOLI Anastasia, UNIMI, Dipartimento di Scienze farmaceutiche, Ricercatore, Farmaceutico Tecnologico Applicativo

GAZZANIGA Andrea, UNIMI, Dipartimento di Scienze farmaceutiche, Professore Ordinario, Farmaceutico Tecnologico Applicativo

GELMI Maria Luisa, UNIMI, Dipartimento di Scienze farmaceutiche, Professore Ordinario, Chimica Organica

GENNARI Chiara, UNIMI, Dipartimento di Scienze farmaceutiche, Ricercatore, Farmaceutico Tecnologico Applicativo

GRAZIOSO Giovanni, UNIMI, Dipartimento di Scienze farmaceutiche, Professore Associato, Chimica Farmaceutica

MARONI Alessandra, UNIMI, Dipartimento di Scienze farmaceutiche, Ricercatore, Farmaceutico Tecnologico Applicativo

MENEGHETTI Fiorella, UNIMI, Dipartimento di Scienze farmaceutiche, Ricercatore, Chimica Farmaceutica

MINGHETTI Paola, UNIMI, Dipartimento di Scienze farmaceutiche, Professore Ordinario, Farmaceutico Tecnologico Applicativo

ORIOLI Marica, UNIMI, Dipartimento di Scienze farmaceutiche, Professore Associato, Chimica Farmaceutica

PALLAVICINI Marco, UNIMI, Dipartimento di Scienze farmaceutiche, Professore Ordinario, Chimica Farmaceutica

PEDRETTI Alessandro, UNIMI, Dipartimento di Scienze farmaceutiche, Professore Associato, Chimica Farmaceutica

RIVA Sergio, CRN, Istituto di Chimica del riconoscimento molecolare, Primo Ricercatore, Chimica Organica

ROMEO Sergio, UNIMI, Dipartimento di Scienze farmaceutiche, Professore Associato, Chimica Farmaceutica

ROSSI Elisabetta, UNIMI, Dipartimento di Scienze farmaceutiche, Professore Ordinario, Chimica Organica

SELMIN Francesca, UNIMI, Dipartimento di Scienze farmaceutiche, Professore Associato, Farmaceutico Tecnologico Applicativo

SPARATORE Anna, UNIMI, Dipartimento di Scienze farmaceutiche, Professore Ordinario, Chimica Farmaceutica

VALOTI Ermanno, UNIMI, Dipartimento di Scienze farmaceutiche, Professore Ordinario, Chimica Farmaceutica

VISTOLI Giulio, UNIMI, Dipartimento di Scienze farmaceutiche, Professore Associato, Chimica Farmaceutica

ZEMA Lucia, UNIMI, Dipartimento di Scienze farmaceutiche, Professore Associato, Farmaceutico Tecnologico Applicativo



Contacts

UNIMI
www.unimi.it/ENG/ is the address of our University’s international portal. The function “who and where" will help you to find each professor.
http://www.unimi.it/chiedove/ENG/chiedove.jsp
CNR
Consiglio Nazionale delle Ricerche, website: http://www.cnr.it/sitocnr/Englishversion/Englishversion.html

Teaching

TEACHING ACTIVITY OF THE PHD COURSE IN PHARMACEUTICAL SCIENCES (ACADEMIC YEAR 2018-19)

ELIGIBLE COURSES OF THE PHD SCHOOL IN PHARMACEUTICAL SCIENCES - R29 (a.a. 2018-19)

“DRUG DISCOVERY AND DEVELOPMENT: AN INDUSTRIAL PERSPECTIVE” (optional course for PhD students in Pharmaceutical Sciences, 20h, 4 cfu).
Professor Giancarlo Aldini is in charge of this course Course schedules: December 2018.

a) Identification of new active principles derived from plants for pharmaceuticals, health foods and personal care. Dr. Paolo Morazzoni - Indena
b) Research & Development in industrial pharmaceutical biotechnology: an overview. Dr. Luigi Colombo - Merck Biopharma
c) Analytical methodologies and technologies in the design and production of biotechnological drugs Dr. Tobias Haas - Merck Biopharma
d) Characterization and profiling of biotechnological drugs. Dr. Carlo E. Giartosio - Merck Biopharma
e) Process development: from lab to industrial scale. Dr. Renato Canevotti - Flamma
f) Quality and regulatory aspects in contract manufacturing projects. Dr. Roberto Salghetti Drioli - Flamma
g) Plant extracts: fields of application and related issues. Dr. Giovanna Nicotra, EPO s.r.l
h) Plant extracts: main topics on analytical and contaminant tests. Dr. Raffaella Gatti, EPO s.r.l.


“APPLICATION OF PEPTIDES AND PROTEINS IN PHARMACEUTICAL SCIENCES (mandatory course for PhD students in Pharmaceutical Sciences, 25h, 5 cfu). Professors Giorgio Abbiati, Giovanni Grazioso, Alessandra Maroni, Fiorella Meneghetti, Sara Pellegrino and Francesca Selmin are in charge of this course. Course schedules: February 2019.

Monday February 18th, 2019
9.15: “Short introduction to the course”
9.30-11.00: “Antimicrobial peptides: design and studies on the mechanism of action”. Prof. Alessandra Romanelli, University of Milan.
11.00-12.30: “Roadmap to a successful industrial transfer for peptides therapeutics: key technical, regulatory, environmental and economic considerations”. Dr. Silvana Cappelletti, Chemi SpA.
14.00-15.30: “Peptide chemistry in drug discovery and new peptide therapeutics”. Prof. Paolo Grieco, University of Naples.
15.30-17.00: “Chemical ligation approaches for protein synthesis and modification”. Dr. Luca D. D’Andrea, Istituto di Biostrutture e Bioimmagini, CNR Torino.

Tuesday February 19th, 2019
9.30-11.00: “Key features of mAb-specific concepts and important pharmacokinetic parameters”. Dr. Mario Regazzi, Società Italiana di Farmacocinetica e Biofarmaceutica (SIFEB), University of Pavia.
11.00-12.30: “Antibody Drug Conjugates (ADCs) in cancer therapy: state of the art and future directions”. Dr. Barbara Valsasina, Nerviano Medical Sciences (Milano).
14.00-15.30: “Peptide-based vehicles for tumor vascular targeting with cytokines”. Prof. Angelo Corti, Università Vita-Salute S. Raffaele, Milan.
15.30-17.00: “Computational design of peptide-based inhibitors”. Dr. Andrea Cavalli, Istituto di Ricerca in Biomedicina, Bellinzona.

Wednesday February 20th, 2019
9.30-11.00: “Biocatalyzed production of active pharmaceutical intermediates". Dr. Sergio Riva - ICRM, CNR Milan.
11.00-12.30: “Identification, production and optimization of enzymes”. Dr. Daniela Monti - ICRM, CNR Milan.
14.00-15.30: “A glimpse of drug discovery through X-ray crystallography”. Dr. Doriano Lamba, Istituto di Cristallografia, CNR Trieste.
15.30-17.00: “Funnel-Metadymanics as accurate binding free energy method”. Prof. Vittorio Limongelli - University of Naples.

“MAIN ASPECTS OF THE DRUG DISCOVERY PROCESS” (optional course for PhD students in Pharmaceutical Sciences, 20h, 4 cfu). Professor Marco De Amici is in charge of this course. Course schedules: April 2019.

a) Target identification and target validation. Dr. Luisa Lanfrancone - IEO (Milano)
b) Screening methodologies assay development. Dr. Ciro Mercurio - IFOM (Milano)
c) Hit finding. Dr. Mario Varasi - IFOM (Milano)
d) Hit to lead process and lead optimization. Dr. Daniele Fancelli - IFOM (Milano)
e) Case histories using the multiparametric lead optimization approach for drugs designed to treat neuropathic pain. Dr. Massimo G. Dondio - Aphad (Milano)
f) Case histories using the multiparametric lead optimization approach for drugs designed to treat respiratory diseases. Dr. Massimo G. Dondio - Aphad (Milano)
g) Allosteric interactions of G protein-coupled receptors and channels and the drug discovery process. Prof. Marco De Amici - UniMi
h) Dimerization of G protein-coupled receptors and the drug discovery process. Prof. Marco De Amici - UniMi


“CHEMOINFORMATICS AND ANALYTICAL APPROACHES IN METABOLOMICS” (optional course for PhD students in Pharmaceutical Sciences, 25h, 5 cfu). Professors Alessandro Pedretti and Giulio Vistoli are in charge of this course. Course schedules: May 2019.

a) The biochemistry of drug metabolism. Prof. Bernard Testa - Losanna
b) Introduction to QSAR and chemometrics. Prof. Roberto Todeschini - UniMi Bicocca
c) Data analysis: Principal Component Analysis. Dr. Davide Ballabio - UniMi Bicocca
d) Data analysis: Parametric statistical analysis. Dr. Ivano Eberini - UniMi
e) Computational approaches to predict metabolism and metabolites. Prof. Giulio Vistoli - UniMi
f) Analytical approaches in drug metabolism. Prof. Giancarlo Aldini - UniMi
g) Drug metabolism, ADMET and in vivo PK: practical approaches. Dr. Giulio Dondio – Aphad
h) Practical session: Principal Component Analysis. Dr. Davide Ballabio - UniMi Bicocca
i) Practical session: Parametric statistical analysis. Dr. Ivano Eberini - UniMi
j) Practical session: Metabolism prediction and QSAR made easy. Prof. Alessandro Pedretti - UniMi

Learning evaluation (approved or not approved) will imply correct (at least 80%) answers of the student to a series of questions elaborated by the teachers of each lesson delivered in the course.

Call for application

Call for application 2016

Applying for a Doctoral Programme

To apply to a Doctoral Progamme candidates must follow the procedure indicated in the specific competition anouncement:

http://www.unimi.it/ricerca/dottorati/15706.htm

The deadline for 2016 application is July 6th, 2016.

The research programs listed for the incoming call are the following:

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Events

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