Accedi al corso

Presentation

PhD in Pharmaceutical Sciences

General informations

Duration: 3 years
Program coordinator: Prof. Giancarlo Aldini

dottorato.scifarm@unimi.it


Outline and objectives

The PhD course in Pharmaceutical Sciences, by offering interdisciplinary training, prepares students for careers in academia and advanced scientific research at a variety of institutions/companies active in the field of drug and health products. The program, which consists of both lectures and intensive experimental research, emphasizes basic as well as applied research in drug discovery and development, drug delivery and targeting, exploiting medicinal chemistry, computational chemistry, pharmaceutics, pharmacokinetics, phytochemistry, and analytical chemistry approaches. Students enjoy the opportunity to enroll in a variety of didactic courses and engage in multidisciplinary research activities. They will gain the knowledge and skills required not only for the rational approach to new biologically active compounds, for the discovery of novel biological pathways in human health and disease, and for the development and delivery of new medications for safe and effective therapy, but also for developing biocides, medical devices, functional foods, food supplements, cosmetic products.


Main scientific research fields

• Design and synthesis of biologically active compounds
• Pharmaceutical, biopharmaceutical and toxicological analysis
• Drug metabolism and pharmacokinetics
• Pharmaceutical technology and legislation
• Food chemistry and food supplements
• Fermentation chemistry and biotechnology
• Advanced synthetic methodologies
• Physico-chemical characterization of biologically active compounds
• Herbal drugs, botanicals and active ingredients of plant origin
• Statistical methods for experimental data processing.


Detailed informations can be found at the following links:

Dipartimento di Scienze Farmaceutiche: http://www.disfarm.unimi.it/ecm/home/ricerca
CNR, Istituto di Chimica per il Riconoscimento Molecolare: http://www.icrm.cnr.it/

Contacts

Director - Secretary - Webmaster Ariel

Director
Prof. Giancarlo Aldini
Dipartimento di Scienze Farmaceutiche, Via Mangiagalli 25, 20133 Milano
e-mail: giancarlo.aldini@unimi.it; Telefono: 02-50319296

Secretary
Dr. Valentina Venuti
Dipartimento di Scienze Farmaceutiche, Via Mangiagalli 25, 20133 Milano
e-mail: valentina.venuti@unimi.it; Telefono: 02-50319337

Webmaster Ariel
Prof. Elisabetta Rossi
Dipartimento di Scienze Farmaceutiche, Via Venezian, 21, 20133 Milano
e-mail: elisabetta.rossi@unimi.it; Telefono: 02-50314474

Academic board

Academic board


ABBIATI Giorgio, UNIMI, Dipartimento di Scienze farmaceutiche, Professore Associato, Chimica Organica

ALDINI Giancarlo, UNIMI, Dipartimento di Scienze farmaceutiche, Professore Ordinario, Chimica Farmaceutica

ARNOLDI Anna, UNIMI, Dipartimento di Scienze farmaceutiche, Professore Ordinario, Chimica degli Alimenti

BERETTA Giangiacomo, UNIMI, Dipartimento di Scienze farmaceutiche, Ricercatore, Chimica Farmaceutica

BOLCHI Cristiano, UNIMI, Dipartimento di Scienze farmaceutiche, Ricercatore, Chimica Farmaceutica

CARINI Marina, UNIMI, Dipartimento di Scienze farmaceutiche, Professore Ordinario, Chimica Farmaceutica

CASIRAGHI Antonella, UNIMI, Dipartimento di Scienze farmaceutiche, Ricercatore, Farmaceutico Tecnologico Applicativo

CEREA Matteo, UNIMI, Dipartimento di Scienze farmaceutiche, Ricercatore, Farmaceutico Tecnologico Applicativo

CHIARI Marcella, CNR, Istituto di Chimica del riconoscimento molecolare, Primo Ricercatore

CHRISTODOULOU Michail, UNIMI, Dipartimento di Scienze farmaceutiche, Ricercatore, Chimica Organica

CILURZO Francesco, UNIMI, Dipartimento di Scienze farmaceutiche, Professore Associato, Farmaceutico Tecnologico Applicativo

CONTINI Alessandro, UNIMI, Dipartimento di Scienze farmaceutiche, Professore Associato, Chimica Organica

DALLANOCE Clelia, UNIMI, Dipartimento di Scienze farmaceutiche, Professore Associato, Chimica Farmaceutica

D'AMATO Alfonsina, UNIMI, Dipartimento di Scienze farmaceutiche, Ricercatore, Chimica Farmaceutica

DE AMICI Marco, UNIMI, Dipartimento di Scienze farmaceutiche, Professore Ordinario, Chimica Farmaceutica

FICO Gelsomina, UNIMI, Dipartimento di Scienze farmaceutiche, Professore Associato, Biologia Farmaceutica

FRANZE' Silvia, UNIMI, Dipartimento di Scienze farmaceutiche, Ricercatore, Farmaceutico Tecnologico Applicativo

FUMAGALLI Laura, UNIMI, Dipartimento di Scienze farmaceutiche, Ricercatore, Chimica Farmaceutica

GAZZANIGA Andrea, UNIMI, Dipartimento di Scienze farmaceutiche, Professore Ordinario, Farmaceutico Tecnologico Applicativo

GELAIN Arianna, UNIMI, Dipartimento di Scienze farmaceutiche, Ricercatore, Chimica Farmaceutica

GELMI Maria Luisa, UNIMI, Dipartimento di Scienze farmaceutiche, Professore Ordinario, Chimica Organica

GENNARI Chiara, UNIMI, Dipartimento di Scienze farmaceutiche, Ricercatore, Farmaceutico Tecnologico Applicativo

GIULIANI Claudia, UNIMI, Dipartimento di Scienze farmaceutiche, Ricercatore, Biologia Farmaceutica

GRAZIOSO Giovanni, UNIMI, Dipartimento di Scienze farmaceutiche, Professore Associato, Chimica Farmaceutica

LAMMI Carmen, Dipartimento di Scienze farmaceutiche, Ricercatore, Chimica degli Alimenti

MARONI Alessandra, UNIMI, Dipartimento di Scienze farmaceutiche, Ricercatore, Farmaceutico Tecnologico Applicativo

MENEGHETTI Fiorella, UNIMI, Dipartimento di Scienze farmaceutiche, Ricercatore, Chimica Farmaceutica

MINGHETTI Paola, UNIMI, Dipartimento di Scienze farmaceutiche, Professore Ordinario, Farmaceutico Tecnologico Applicativo

PALLAVICINI Marco, UNIMI, Dipartimento di Scienze farmaceutiche, Professore Ordinario, Chimica Farmaceutica

PEDRETTI Alessandro, UNIMI, Dipartimento di Scienze farmaceutiche, Professore Associato, Chimica Farmaceutica

PELLEGRINO Sara, UNIMI, Dipartimento di Scienze farmaceutiche, Professore Associato, Chimica Organica

REGAZZONI Luca, UNIMI, Dipartimento di Scienze farmaceutiche, Ricercatore, Chimica Farmaceutica

RIMOLDI Isabella, UNIMI, Dipartimento di Scienze farmaceutiche, Ricercatore, Chimica Generale ed Inorganica

RIVA Sergio, CNR, Istituto di Chimica del riconoscimento molecolare, Primo Ricercatore, Chimica Organica

RODA Gabriella, UNIMI, Dipartimento di Scienze farmaceutiche, Ricercatore, Chimica Farmaceutica

ROMANELLI Alessandra, UNIMI, Dipartimento di Scienze farmaceutiche, Professore Associato, Chimica Generale ed Inorganica

ROSSI Elisabetta, UNIMI, Dipartimento di Scienze farmaceutiche, Professore Ordinario, Chimica Organica

SECUNDO Francesco, CNR, Istituto di Chimica del riconoscimento molecolare, Ricercatore, Chimica Farmaceutica

SELMIN Francesca, UNIMI, Dipartimento di Scienze farmaceutiche, Professore Associato, Farmaceutico Tecnologico Applicativo

SPARATORE Anna, UNIMI, Dipartimento di Scienze farmaceutiche, Professore Ordinario, Chimica Farmaceutica

VALOTI Ermanno, UNIMI, Dipartimento di Scienze farmaceutiche, Professore Ordinario, Chimica Farmaceutica

VILLA Stefania, UNIMI, Dipartimento di Scienze farmaceutiche, Ricercatore, Chimica Farmaceutica

VISTOLI Giulio, UNIMI, Dipartimento di Scienze farmaceutiche, Professore Associato, Chimica Farmaceutica

ZEMA Lucia, UNIMI, Dipartimento di Scienze farmaceutiche, Professore Associato, Farmaceutico Tecnologico Applicativo



Contacts

UNIMI
www.unimi.it/ENG/ is the address of our University’s international portal. The function “who and where" will help you to find each professor.
http://www.unimi.it/chiedove/ENG/chiedove.jsp
CNR
Consiglio Nazionale delle Ricerche, website: http://www.cnr.it/sitocnr/Englishversion/Englishversion.html

Teaching

TEACHING ACTIVITY OF THE PHD COURSE IN "PHARMACEUTICAL SCIENCES" (ACADEMIC YEAR 2021-22)

ELIGIBLE COURSES OF THE PHD COURSE IN PHARMACEUTICAL SCIENCES - R29 (ACADEMIC YEAR 2021-22)

“APPLICATION OF PEPTIDES AND PROTEINS IN PHARMACEUTICAL SCIENCES" (optional for PhD students in Pharmaceutical Sciences, 25h, 5 credits).
Prof. Alessandra ROMANELLI is in charge of this course, which is scheduled for January 2022.

a) Short introduction to the course. Giancarlo ALDINI and Marco DE AMICI - University of Milan.
b) Antimicrobial peptides: design and studies on the mechanism of action. Alessandra ROMANELLI, University of Milan.
c) Roadmap to a successful industrial transfer for peptides therapeutics: key technical, regulatory, environmental and economic considerations”.
d) Peptide chemistry in drug discovery and new peptide therapeutics.
e) Chemical ligation approaches for protein synthesis and modification”.
f) Key features of mAb-specific concepts and important pharmacokinetic parameters.
g) Antibody Drug Conjugates (ADCs) in cancer therapy: state of the art and future directions.
h) Peptide-based vehicles for tumor vascular targeting with cytokines.
i) Computational design of peptide-based inhibitors”.
l) Biocatalyzed production of active pharmaceutical intermediates.
m) Identification, production, and optimization of enzymes.
n) A glimpse of drug discovery through X-ray crystallography.
o) Funnel-Metadymanics as accurate binding free energy method.

“THE DRUG DISCOVERY PROCESS: DEVELOPMENT OF A CLINICAL CANDIDATE” (mandatory for PhD students in Pharmaceutical Sciences, 25h, 5 credits).
Prof. Giancarlo ALDINI is in charge of this course, which is scheduled on February, 14-16 2022.

a) Welcome and introductory remarks. Giancarlo ALDINI and Marco DE AMICI - University of Milan.
b) From drug discovery to pilot plant manufacturing: the secrets of process scale-up. Lorenzo CARUANA and Paul Heinrich WIEDENAU - Aptuit-Evotec.
c) Entrectinib: early process R&D in support of first clinical studies. Ilaria CANDIANI, NerPharMa.
d) Primum non nocere: the pre-clinical safety evaluation. Marina MARINOVICH, University of Milan.
e) Methodology of clinical research and the clinical study protocol. Marco SCATIGNA - Centro Cardiologico Monzino.
f) Clinical trial management and Good Clinical Practice (GCP). Lorenzo COTTINI - High Research - Evidenze Group.
g) Investigational Medicinal Products (IMPs): from design to clinical supply. Cristina MACELLONI - Cosmo Pharmaceuticals.
h) Bioanalysis: a pivotal tool across development. Alessandro GRECO - Aptuit-Evotec.
i) Statistical and pharmacokinetic analysis across the different phases of a clinical development. Andrea NIZZARDO and Alessia TAGLIAVINI - Aptuit-Evotec.
l) Pharmaceutical development at a glance. Giuseppe COLOMBO - Italfarmaco SpA.
m) Pharmaceutical development of solid oral dosage forms, particularly for modified release: rules and examples. Luigi MORO - Pharmaceutical Development Expert.
n) Drug product continuous manufacturing: evolution or revolution? Giustino DI PRETORO - Janssen R&D.
o) A regulatory journey from discovery to patients: steps and actors. Paola TOCCHETTI - Aptuit-Evotec.

“HPC@UNIMI: INDACO FOR CHEMOINFORMATIC AND BIOPHYSICAL APPROACHES IN DRUG DISCOVERY” (optional for PhD students in Pharmaceutical Sciences, 10h, 2 credits).
Prof. Giovanni GRAZIOSO is in charge of this course, which is scheduled for April 2022.

a) HPC@UNIMI: Indaco as a computing infrastructure for mathematical-statistical applications, molecular modeling, and "omics" techniques.
b) HPC@Indaco, basic concepts of computers and networks, UNIX, installation of applications and access to the platform, applications’ optimization, and management.
c) Chemoinformatics in drug discovery: ligand- and structure-based approaches.
d) Biophysical approaches in drug discovery: general overview and applied techniques.
Course teachers: Giovanni GRAZIOSO, Angelica MAZZOLARI, Franco LEVERARO, Uliano GUERRINI, Giulio VISTOLI - University of Milan.

“BIOCATALYTIC APPROACHES TO THE SYNTHESIS OF ENANTIOPURE DRUG SUBSTANCES" (optional for PhD students in Pharmaceutical Sciences, 10h, 2 credits).
Prof. Marco DE AMICI is in charge of this course, which is scheduled for May 2022.

a) Introduction to biocatalysis and main classes of enzymes. Sergio RIVA – IRCM, CNR Milan.
b) Overview on the use of proteins for pharmaceutical applications and, more specifically, of enzymatic formulations in biocatalysis. Francesco SECUNDO – IRCM, CNR Milan.
b) The relevance of chirality in medicinal chemistry. Marco DE AMICI - University of Milan.
b) Biocatalyzed processes for the production of Active Pharmaceutical Ingredients (APIs): case examples. Sergio RIVA – IRCM, CNR Milan.

“BASIC STATISTICS FOR BIOLOGICAL DATA” (optional for PhD students in Pharmaceutical Sciences, 10h, 2 credits).
Prof. Gian Enrico ROVATI is in charge of this course, which is scheduled for September 2022.
Course teachers: Gian Enrico ROVATI, Annalisa ORENTI - University of Milan.

“MASS SPECTROMETRY APPLICATIONS IN DRUG DISCOVERY” (optional for PhD students in Pharmaceutical Sciences, 15h, 3 credits).
Prof. Giancarlo ALDINI is in charge of this course, which is scheduled for September 2022.
Course teachers: Giancarlo ALDINI, Alessandra ALTOMARE, Giovanna BARON - University of Milan.

Learning evaluation (approved or not approved) will imply correct (at least 80%) answers of the student to a series of questions elaborated by the teachers for each lesson delivered in a course.

Call for application

Events

PhD Course "THE DRUG DISCOVERY PROCESS: DEVELOPMENT OF A CLINICAL CANDIDATE" - February 14-16 2022

The PhD course mainly addressed to the PhD students in "Pharmaceutical Sciences" will take place from February 14th to 16th 2022.
Lessons will be delivered in presence (Room C13, via L. Mangiagalli 25) and online through the MICROSOFT TEAMS platform.
See the program in the attached file.