Teaching activity scheduled for 2020/2021
Course for the PhD Students in Pharmaceutical Sciences
THE DRUG DISCOVERY PROCESS:
FROM TARGET TO LEAD IDENTIFICATION
A short introduction to the course
Giancarlo ALDINI, Coordinator of the PhD course - February
The drug discovery process from target to leads: an overview
Tiziano BANDIERA, IIT Genoa - February
Target identification and target validation
Luisa LANFRANCONE, IEO Milan - February
Hit ID: from theory to real cases
Fabio BERTOZZI, IIT Genoa - February
Hit identification approaches
Ciro MERCURIO, IFOM Milan - February
Organism-based strategies for drug discovery
Simona MASIERO, University of Milan - February 18th, 09:30
Computer-aided drug discovery and design in the hit finding process
Francesca GRISONI, ETH Zurich - February
Drug design in the exscale supercomputers era - The EXCALE.EU Project
Andrea BECCARI, Dompé SpA - February
Practical approaches for ADMET parameters optimization during the drug discovery phase
Giulio DONDIO, Aphad Milan - February
Hit to lead: novel, selective and developable dopamine D3 antagonists with modified “amino” region
Fabrizio MICHELI, Aptuit Verona - February
Statistical learning and deep artificial neural networks: selected applications in drug discovery
Toni GIORGINO, Istituto di Biofisica (IBF-CNR) Milano - February
TEACHING ACTIVITY OF THE PHD COURSE IN PHARMACEUTICAL SCIENCES (ACADEMIC YEAR 2018-19)
ELIGIBLE COURSES OF THE PHD SCHOOL IN PHARMACEUTICAL SCIENCES - R29 (a.a. 2018-19)
“DRUG DISCOVERY AND DEVELOPMENT: AN INDUSTRIAL PERSPECTIVE” (optional course for PhD students in Pharmaceutical Sciences, 20h, 4 cfu).
Professor Giancarlo Aldini is in charge of this course Course schedules: December 2018.
a) Identification of new active principles derived from plants for pharmaceuticals, health foods and personal care. Dr. Paolo Morazzoni - Indena
b) Research & Development in industrial pharmaceutical biotechnology: an overview. Dr. Luigi Colombo - Merck Biopharma
c) Analytical methodologies and technologies in the design and production of biotechnological drugs Dr. Tobias Haas - Merck Biopharma
d) Characterization and profiling of biotechnological drugs. Dr. Carlo E. Giartosio - Merck Biopharma
e) Process development: from lab to industrial scale. Dr. Renato Canevotti - Flamma
f) Quality and regulatory aspects in contract manufacturing projects. Dr. Roberto Salghetti Drioli - Flamma
g) Plant extracts: fields of application and related issues. Dr. Giovanna Nicotra, EPO s.r.l
h) Plant extracts: main topics on analytical and contaminant tests. Dr. Raffaella Gatti, EPO s.r.l.
“APPLICATION OF PEPTIDES AND PROTEINS IN PHARMACEUTICAL SCIENCES (mandatory course for PhD students in Pharmaceutical Sciences, 25h, 5 cfu). Professors Giorgio Abbiati, Giovanni Grazioso, Alessandra Maroni, Fiorella Meneghetti, Sara Pellegrino and Francesca Selmin are in charge of this course. Course schedules: February 2019.
Monday February 18th, 2019
9.15: “Short introduction to the course”
9.30-11.00: “Antimicrobial peptides: design and studies on the mechanism of action”. Prof. Alessandra Romanelli, University of Milan.
11.00-12.30: “Roadmap to a successful industrial transfer for peptides therapeutics: key technical, regulatory, environmental and economic considerations”. Dr. Silvana Cappelletti, Chemi SpA.
14.00-15.30: “Peptide chemistry in drug discovery and new peptide therapeutics”. Prof. Paolo Grieco, University of Naples.
15.30-17.00: “Chemical ligation approaches for protein synthesis and modification”. Dr. Luca D. D’Andrea, Istituto di Biostrutture e Bioimmagini, CNR Torino.
Tuesday February 19th, 2019
9.30-11.00: “Key features of mAb-specific concepts and important pharmacokinetic parameters”. Dr. Mario Regazzi, Società Italiana di Farmacocinetica e Biofarmaceutica (SIFEB), University of Pavia.
11.00-12.30: “Antibody Drug Conjugates (ADCs) in cancer therapy: state of the art and future directions”. Dr. Barbara Valsasina, Nerviano Medical Sciences (Milano).
14.00-15.30: “Peptide-based vehicles for tumor vascular targeting with cytokines”. Prof. Angelo Corti, Università Vita-Salute S. Raffaele, Milan.
15.30-17.00: “Computational design of peptide-based inhibitors”. Dr. Andrea Cavalli, Istituto di Ricerca in Biomedicina, Bellinzona.
Wednesday February 20th, 2019
9.30-11.00: “Biocatalyzed production of active pharmaceutical intermediates". Dr. Sergio Riva - ICRM, CNR Milan.
11.00-12.30: “Identification, production and optimization of enzymes”. Dr. Daniela Monti - ICRM, CNR Milan.
14.00-15.30: “A glimpse of drug discovery through X-ray crystallography”. Dr. Doriano Lamba, Istituto di Cristallografia, CNR Trieste.
15.30-17.00: “Funnel-Metadymanics as accurate binding free energy method”. Prof. Vittorio Limongelli - University of Naples.
“MAIN ASPECTS OF THE DRUG DISCOVERY PROCESS” (optional course for PhD students in Pharmaceutical Sciences, 20h, 4 cfu). Professor Marco De Amici is in charge of this course. Course schedules: April 2019.
a) Target identification and target validation. Dr. Luisa Lanfrancone - IEO (Milano)
b) Screening methodologies assay development. Dr. Ciro Mercurio - IFOM (Milano)
c) Hit finding. Dr. Mario Varasi - IFOM (Milano)
d) Hit to lead process and lead optimization. Dr. Daniele Fancelli - IFOM (Milano)
e) Case histories using the multiparametric lead optimization approach for drugs designed to treat neuropathic pain. Dr. Massimo G. Dondio - Aphad (Milano)
f) Case histories using the multiparametric lead optimization approach for drugs designed to treat respiratory diseases. Dr. Massimo G. Dondio - Aphad (Milano)
g) Allosteric interactions of G protein-coupled receptors and channels and the drug discovery process. Prof. Marco De Amici - UniMi
h) Dimerization of G protein-coupled receptors and the drug discovery process. Prof. Marco De Amici - UniMi
“CHEMOINFORMATICS AND ANALYTICAL APPROACHES IN METABOLOMICS” (optional course for PhD students in Pharmaceutical Sciences, 25h, 5 cfu). Professors Alessandro Pedretti and Giulio Vistoli are in charge of this course. Course schedules: May 2019.
a) The biochemistry of drug metabolism. Prof. Bernard Testa - Losanna
b) Introduction to QSAR and chemometrics. Prof. Roberto Todeschini - UniMi Bicocca
c) Data analysis: Principal Component Analysis. Dr. Davide Ballabio - UniMi Bicocca
d) Data analysis: Parametric statistical analysis. Dr. Ivano Eberini - UniMi
e) Computational approaches to predict metabolism and metabolites. Prof. Giulio Vistoli - UniMi
f) Analytical approaches in drug metabolism. Prof. Giancarlo Aldini - UniMi
g) Drug metabolism, ADMET and in vivo PK: practical approaches. Dr. Giulio Dondio – Aphad
h) Practical session: Principal Component Analysis. Dr. Davide Ballabio - UniMi Bicocca
i) Practical session: Parametric statistical analysis. Dr. Ivano Eberini - UniMi
j) Practical session: Metabolism prediction and QSAR made easy. Prof. Alessandro Pedretti - UniMi
Learning evaluation (approved or not approved) will imply correct (at least 80%) answers of the student to a series of questions elaborated by the teachers of each lesson delivered in the course.